Once you have sufficient reason to believe they are in fact missing, contact your local law enforcement agency to make a missing persons report. Police will need details like the missing person's photo, date of birth, address, physical description, clothing last seen wearing and other details of the life of your missing person. Make it a routine to take at least one head and shoulders photograph of
your loved ones each year. Please be complete with the information you provide to law enforcement; it's always better to have too much information, than not enough.